Orygn triGLP — Clinical Studies & Scientific Dossier

ORYGN triGLP — Clinical Studies & Scientific Dossier. Performance Aging & Metabolic Health triGLP is a proprietary, patent-protected bioactive peptide mix derived from fresh Atlantic salmon from Norway. It provides "Performance Aging" via improved metabolic efficiency, with clinically proven benefits in an active, targeted way: drives fat loss, protects overall muscle mass, and boosts energy levels. The optimal mix stimulates GLP-1, GIP (metabolism), and GLP-2 (gut health), plus potent anti-inflammatory and antioxidant effects. A powerful partnership — from fish to finished product Patented gentle enzymatic hydrolysis processing. Only fresh sashimi-grade Norwegian salmon is used. 33% salmon off-cuts upcycled; 67% from partners producing high-quality salmon fillets. Material arrives at facility within hours at less than 4°C. Water + enzymes + salmon → oil, peptides, collagen. 100% human grade, no additives, no antibiotics, non-GMO, zero waste, circular economy. >99% protein, >35% type I and III collagen. Unique bioactive peptides Fourier-transform infrared fingerprint mapping shows triGLP has a different peptide composition from 1,324 commercially available and research-based hydrolysates produced by other protease enzymes (Alcalase, Corolase, Flavourzyme, Protamex, Papain). triGLP stands out as unique. Faster absorption for recovery Up to 100% pure protein with type I & III collagen. Patent-protected and trade secrets. +67.5% more absorption than highly hydrolyzed whey protein (WPH) over just 2 hours. Higher bioavailability, better digestibility, light stomach feel. Tested vs WPH and regular whey protein isolate (WPI). Why triGLP is different — unique health benefits & mode of action - GLP-1, GIP & GLP-2 — supporting weight control and better gut health - Protecting muscle mass - Boosting energy levels - New and unique health claims Advanced science: powerful gene expression modulation - >3x FTH1 upregulation: improves iron absorption, enhances energy levels, no adverse effects of iron supplementation - >3x HMOX1 upregulation: supports GI health via important targeted protective pathways, provides antioxidant benefits - >3x ALOX-12 downregulation: increases fat burn, increases insulin sensitivity, better body profile and weight control Regulatory status Classified as a New Dietary Ingredient (NDI) by the US FDA with self-GRAS. Health Canada Approved Qualified Health Claims for iron metabolism, metabolic efficiency, and skin. US FDA Structure-Function claims cover ferritin and hemoglobin support, red blood cell production, iron-rich blood, antioxidant action, GI and immune support, healthy response to gut inflammation, energy utilization, and skin health. GLP-1 & better metabolic health Over 70% of US adults are overweight or obese. Average BMI increases by 1.5 per decade. A 40-year-old with a BMI of 27 averages BMI 31.25 by age 65. A preventative approach is urgently needed. GLP-1 based healthy fat loss with triGLP triGLP consistently shows a 6-7% reduction in BMI via reduction in body fat only. Assayed for GLP-1 and GIP activity to determine the mode of action of weight loss. Clinical study: metabolic health 14 healthy subjects, 12 g/day, 8 weeks. triGLP vs whey body mass and metabolic metrics. Significant declines in inflammatory markers TNF and IL-6 (strongly associated with ill health). Marked increase in ferritin, reflecting improved iron stores and a better ability to use oxygen. Result: leaner, healthier body with more energy. Clinical study: overweight subjects 48 overweight subjects, 16 g/day, 6 weeks. Significant change in BMI. Significant reductions in inflammation: IL-6 reduced by 15%. Published: Framroze et al., J. of Obesity & Weight Loss Therapy 2016. triGLP protects against muscle mass loss In vitro assays show dose-dependent inhibition of activin and myostatin by peptides contained in SPHi (presented at MASCC 2023). This suggests SPH can protect muscle mass combined with the weight loss effects of its GLP-1 effects. Key benefits of GLP-2 activation SPH showed 1.3-fold and 2.6-fold increase in GLP-2 receptor signaling at 1 mg/ml and 10 mg/ml; lab standard GLP-2 agonist showed a 3.8-fold increase. This suggests SPH supports GI health and helps avoid inadequate protein intake/absorption seen in weight-loss programs including GLP-1 drugs. triGLP and improved glucose metabolism Consistently shows 3-6% reduction in fasting blood glucose and improved energy levels in clinical studies. In vitro studies assess both insulin-dependent and independent mechanisms of action. Increase in glucose uptake in muscles Provides: increased energy for an active lifestyle, better regulation of blood glucose levels, better metabolic health with lower inflammatory levels and less stress on the body. Clinical study: energy, vitality & mood 20 healthy subjects, 4 g/day, 128 days. Safety study for Health Canada QHCs. Anti-inflammatory effects via significant increase in IL-10. Less red blood cell variability demonstrating less stress on the body. Significant HMOX1 increase for protecting gut health. Better overall wellbeing. The same benefits from 4 g to 16 g doses. Publication pending. Clinical study: energy improvement 24 subjects, 4 g/day, 4 weeks. On Day 1, 100% (18/24) of subjects reported moderate to low energy levels. By Day 28, significant shift toward high/very high energy levels. Statistically significant at 90% confidence level. Clinical study: gut health (Stanford Research) triGLP upregulates anti-oxidative gene expression to support gut health and protect against inflammation. Standard mouse model of inflammatory bowel disease (IBD). triGLP bioactive peptides provided faster recovery for the gut and overall health via an increase in HMOX1 and FTH1. This was NOT a nutritional effect — control peptides (Vital Protein) had no benefit. The group fed bovine collagen peptides suffered severe damage to the gut. Published: Wei, Tao, Sylvester et al., Biomolecules 2022, 12, 1287. Summary & conclusions triGLP upregulates HMOX-1, an antioxidant gene system needed to sustain and enhance GI health. triGLP supports gut health and overall health by rebalancing the immune system and resolving inflammation and oxidative stress.